News and Events

November, 2016

Shu Meng, MD, PhD and Gianfranco Matrone, PhD, both post-doctoral fellows in John Cooke Lab, were selected as finalists for the 2016 Council on Arteriosclerosis, Thrombosis and Vascular Biology (ATVB) Early Career Investigator Award.  Only five finalists were selected worldwide for this award that recognizes the council’s early career investigator members who are performing high quality research. Shu’s abstract was entitled “LMO2 is required for endothelial proliferation, angiogenesis and tissue regeneration”. Lim-domain only (LMO) 2 is a key transcription factor in embryonic angiogenesis.  However, her work was the first to identify its role in adult endothelial function and tissue regeneration. The title of Gianfranco’s abstract was “LMO2 modulates SPHK1 and promotes endothelial cell migration”. His study expanded on the findings of Shu Meng and identified SPHK1 as a downstream effector of LMO2. He determined that LMO2 protein-SPHK1 gene interaction is essential for intersegmental vessel formation and endothelial cell migration.

Photo: Our colleagues at American Heart Association conference, 2016
From left to right: Rajarajan Amirthalingam thandavarayan, PhD, John Cooke, MD, PhD, Shu Meng, MD, PhD, Gianfranco Matrone, PhD and Palas Chanda, PhD. 

John Cooke, MD, PhD and his former post-doctoral fellow, Gautham Yepuri, PhD, were honored with the Best Manuscript Award by Circulation Research at the editorial board dinner during the American Heart Association Scientific Sessions 2016 in New Orleans, Louisiana.  Five papers were recognized among all the original research articles published in Circulation Research within the last year.  Their manuscript was selected by the Editors because it met high standards of scientific excellence in terms of novelty, impact, and methodology; it has been widely read online following publication, and represents some of the very best work published in Circulation Research.  This study was the first to identify a biological link between vascular dysfunction and chronic proton pump inhibitor exposure that has been associated with increased risk of cardiovascular, renal and neurological morbidity and mortality. View manuscript. 

Adrian Balogh, MS, John P. Cooke, MD, PhD and Ivone Bruno, PhD (left to right) stand in front of a poster presented by Balogh at the poster session during the 2016 Kostas Cardiovascular Nanotherapeutics Meeting George and Angelina Kostas Research Center for Cardiovascular Nanomedicine Annual International Meeting, 2016. Balogh presented the work that Houston Methodist Research Institute is doing in conjunction with Northeastern University, using micro-RNAs to treat inflammation and atherosclerotic plaques.

John P. Cooke, MD, PhD and Roman Sukhovershin, MD, PhD (left to right) stand in front of a poster presented by Sukhovershin at the poster session during the George and Angelina Kostas Research Center for Cardiovascular Nanomedicine Annual International Meeting, 2016.  Sukhovershin presented the work that Houston Methodist Research Institute is doing in conjunction with Northeastern University, using leukocyte-inspired nanovesicles to target the inflamed vasculature.

Congratulations to the Center for Cardiovascular Regeneration

All abstracts submitted from the Center for Cardiovascular Regeneration were accepted for presentation at the American Heart Association (AHA) meeting. The selection of abstracts for the AHA meeting is rigorous, with less than 20% selected for final presentation. John Cooke, MD, PhD, has been invited to speak at the "Best of Circulation Research" session about his proton pump inhibitor and vascular aging research. And most notably, in the Young Investigator Session, where 4 young investigators are competing for the prize, our center has two. Congratulations to everyone from the Center for Cardiovascular Regeneration for their great work and success. 

• Renfeng Mao (Apoa1 Binding Protein Inhibits Retinal Angiogenesis) - Poster
• Li Lai (A Glycolytic Switch is Required for Transdifferentiation) – Poster
• Palas Chanda (Innate Immune Activation is Required for Regeneration) - Oral Presentation
• John Cooke - Speaker at "Best of Circulation Research" session
• Gianni Matrone and Shu Meng - Young Investigator Session