Dr. Rostomily has a long-standing clinical and research interest in neuro-oncology. His clinical specialties are skull base surgery and stereotactic radiosurgery. He is the director of Translational Research for the Houston Methodist department of Neurosurgery and Co-Director of the new Houston Methodist Gamma Knife Center slated to open early in 2018. His research interests include i) understanding basic mechanisms of glioma invasion and epithelial mesenchymal transition (EMT) and their potential as therapeutic targets, ii) patient derived organotypic slice cultures and 3D tissue engineered tumors-on-chip as platforms for pre-clinical therapeutic screening on microfluidic devices to enhance precision cancer medicine, iii) the implications of aging and genomic instability on intra-tumoral molecular heterogeneity and treatment responses, and iv) characterizing the electro-physiologic properties of gliomas (the “Electrome”) to identify new therapies and mitigate tumor related morbidity. When not dissecting the brain, he is busy smoking a mean brisket and playing with his chocolate labrador.
Sr. Research Assistant
Naze earned her Ph.D. in biomedical engineering from the University of Houston. Her graduate studies led to the development of in vitro 3D Glioblastoma models using hydrogel-based microwells, where she investigated the signaling pathways that play role in the interaction of tumor cells with the microenvironment. She also investigated the therapeutic effect of Delta-24RGD on in vitro 3D tumor models. She showed that microwell platform helps tumor to mimic the in vivo tumor microenvironment and can be used as a robust tool to investigate the oncolytic potential of the viruses in vitro. Prior to joining Dr. Rostomily lab in February 2018, Naze worked as a postdoctoral fellow for the Neurosurgery Department at MD Anderson Cancer Center, focusing on understanding the molecular signaling pathways and gene regulatory events that promote angiogenesis and its role in Glioblastoma. In her free time, Naze enjoys outdoors often running, camping, travelling and playing hang drum.
Sr. RESEARCH Assistant
Pooja earned MS in Microbiology from India and MS in Cell and Molecular Biology from Long Island University, New York. After completion of her MS in Microbiology, she joined Wockhardt Research Center where she conducted Bioefficacy and Bioidentity studies for erythropoietin and insulin. Later with her degree in Molecular Biology, she joined Center for stem cell and Regenerative Medicine, University of Texas Health Science Center where she worked on ex vivo expansion of Human Hematopoietic stem cells and gene editing using ZFNs. After that she worked on NOTCH signaling pathway in the process of Spermatogenesis at M D Anderson Cancer Center. In order to better understand the specific regulation of RBPJ which is central player of NOTCH signaling and its downstream targets, she used Yeast-2-hybrid assay with RBPJ as bait and discovered novel binding partner called BHC80. She then confirmed protein-protein interactions via co-ip as well as mass spectrometry. Her recent poster presentation on finding novel binding partners of RBPJ received an outstanding award at TFRS conference. Pooja enjoys travelling, camping, hiking and painting.
Maga, who is originally from Spain, has a histotechnologist degree from University of Texas-M.D. Anderson Cancer Center. She has multiple years experience working in animal models. Maga joined the Rostomily lab to perform immunohistochemistry, rodent surgeries and various other GBM projects including ones in collaboration with the Neural Biorepository at Houston Methodist. She enjoys mountain biking, racing and photography during her free time.
- Maria Elias. Scientist Myriad Genetics, Salt Lake City, Utah.
- Rob Oxford, MD, University of Washington, Seattle
- Sutapa Ray, Business Development Manager Impel NeuroPharma, Seattle WA
- Elizabeth Stoll, CANDO Research Fellow Newcastle University UK
- Mari Tokita, Post-doctoral Associate, Mol. & Human Gen./Diag Lab Admin
- Baylor College of Medicine, Houston, TX
- Hunter Underhill; Assistant Professor Pediatrics Univ of Utah.
- Rohan Ramakrishna, Assistant Professor of Neurosurgery Weil Cornell Medical center
- Kathleen Tozer
- Liza Severs, Graduate Student, University of Washington, Seattle
- Lisa Horowitz, Post-doctoral Fellow-Pathology University of Washington, Seattle, WA