Rosato lab Publications


Molecular bases determining daptomycin resistance-mediated resensitization to ß-lactams (seesaw effect) in methicillin-resistant Staphylococcus aureus
Renzoni, A, Kelley, WL, Rosato, RR, Martinez, MP, Roch, M, Fatouraei, M, Haeusser, DP, Margolin, W, Fenn, S, Turner, RD, Foster, SJ & Rosato, AE 2017, Antimicrobial Agents and Chemotherapy, vol 61, no. 1, e01634-16. DOI:

Modeling meropenem treatment, alone and in combination with daptomycin, for KPC-producing Klebsiella pneumoniae strains with unusually low carbapenem MICs
Gagetti, P, Pasteran, F, Martinez, MP, Fatouraei, M, Gu, J, Fernandez, R, Paz, L, Rose, WE, Corso, A & Rosato, AE 2016, Antimicrobial Agents and Chemotherapy, vol 60, no. 8, pp. 5047-5050. DOI:

The staphylococcus aureus chaperone PrsA is a new auxiliary factor of oxacillin resistance affecting penicillin-binding protein 2A
Jousselin, A, Manzano, C, Biette, A, Reed, P, Pinho, MG, Rosato, AE, Kelley, WL & Renzoni, A 2016, Antimicrobial Agents and Chemotherapy, vol 60, no. 3, pp. 1656-1666. DOI:

Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus
Santos Costa, S, Viveiros, M, Rosato, AE, Melo-Cristino, J & Couto, I 2015, BMC microbiology, vol 15, pp. 232. DOI:

Impact of efflux in the development of multidrug resistance phenotypes in Staphylococcus aureus
Costa, SS, Viveiros, M, Rosato, AE, Melo-Cristino, J & Couto, I 2015, BMC Microbiology, vol 15, no. 1, 232. DOI:

Iron- and hemin-dependent gene expression of Porphyromonas gingivalis
Anaya-Bergman, C, Rosato, A & Lewis, JP 2015, Molecular Oral Microbiology, vol 30, no. 1, pp. 39-61. DOI:

PBP2a mutations causing high-level ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates
Long, SW , Olsen, RJ, Mehta, SC, Palzkill, T, Cernoch, PL, Perez, KK, Musick, WL, Rosato, AE & Musser, JM 2014, Antimicrobial Agents and Chemotherapy, vol 58, no. 11, pp. 6668-6674. DOI:

Ceftaroline is active against heteroresistant methicillin-resistant Staphylococcus aureus clinical strains despite associated mutational mechanisms and intermediate levels of resistance
Fernandez, R, Paz, LI, Rosato, RR & Rosato, AE 2014, Antimicrobial Agents and Chemotherapy, vol 58, no. 10, pp. 5736-5746. DOI:

Ceftaroline is active against heteroresistant methicillin-resistant Staphylococcus aureus clinical strains despite associated mutational mechanisms and intermediate levels of resistance
Fernandez, R, Paz, LI, Rosato, RR & Rosato, AE 2014, Antimicrobial Agents and Chemotherapy, vol 58, no. 10, pp. 5736-5746. DOI:

TCA cycle-mediated generation of ROS is a key mediator for HeR-MRSA survival under ß-lactam antibiotic exposure
Rosato, RR, Fernandez, R, Paz, LI, Singh, CR & Rosato, AE 2014, PLoS ONE, vol 9, no. 6, e99605. DOI:

Staphylococcal phenotypes induced by naturally occurring and synthetic membrane-interactive polyphenolic ß-lactam resistance modifiers
Palacios, L, Rosado, H, Micol, V, Rosato, AE, Bernal, P, Arroyo, R, Grounds, H, Anderson, JC, Stabler, RA & Taylor, PW 2014, PLoS ONE, vol 9, no. 4, e93830. DOI:

Identification of point mutations in clinical staphylococcus aureus strains that produce small-colony variants auxotrophic for menadione
Dean, MA, Olsen, RJ, Wesley Long, S, Rosato, AE & Musser, JM 2014, Infection and Immunity, vol 82, no. 4, pp. 1600-1605. DOI:

Exposure of Clinical MRSA Heterogeneous Strains to ß-Lactams Redirects Metabolism to Optimize Energy Production through the TCA Cycle
Keaton, MA, Rosato, RR, Plata, KB, Singh, CR & Rosato, AE 2013, PLoS ONE, vol 8, no. 8, e71025. DOI:

Targeting of PBP1 by ß-lactams Determines recA/SOS Response Activation in Heterogeneous MRSA Clinical Strains
Plata, KB, Riosa, S, Singh, CR, Rosato, RR & Rosato, AE 2013, PLoS ONE, vol 8, no. 4, e61083. DOI:

ß-lactams increase the antibacterial activity of daptomycin against clinical methicillin-resistant Staphylococcus aureus strains and prevent selection of daptomycin-resistant derivatives
Mehta, S, Singh, C, Plata, KB, Chanda, PK, Paul, A, Riosa, S, Rosato, RR & Rosato, AE 2012, Antimicrobial Agents and Chemotherapy, vol 56, no. 12, pp. 6192-6200. DOI:

A crossover trial of antimicrobial scrubs to reduce methicillin-resistant Staphylococcus aureus burden on healthcare worker apparel
Bearman, GML, Rosato, A, Elam, K, Sanogo, K, Stevens, MP, Sessler, CN & Wenzel, RP 2012, Infection Control and Hospital Epidemiology, vol 33, no. 3, pp. 268-275. DOI:

Thiadiazolidinones: A new class of alanine racemase inhibitors with antimicrobial activity against methicillin-resistant Staphylococcus aureus
Ciustea, M, Mootien, S, Rosato, AE, Perez, O, Cirillo, P, Yeung, KR, Ledizet, M, Cynamon, MH, Aristoff, PA, Koski, RA, Kaplan, PA & Anthony, KG 2012, Biochemical Pharmacology, vol 83, no. 3, pp. 368-377. DOI:

VraSR two-component regulatory system contributes to mprF-mediated decreased susceptibility to daptomycin in in vivo-selected clinical strains of methicillin-resistant Staphylococcus aureus
Mehta, S, Cuirolo, AX, Plata, KB, Riosa, S, Silverman, JA, Rubio, A, Rosato, RR & Rosato, AE 2012, Antimicrobial Agents and Chemotherapy, vol 56, no. 1, pp. 92-102. DOI:


Oxacillin- and cefoxitin-susceptible meticillin-resistant Staphylococcus aureus (MRSA)
Cuirolo, A, Canigia, LF, Gardella, N, Fernández, S, Gutkind, G, Rosato, A & Mollerach, M 2011, International Journal of Antimicrobial Agents, vol 37, no. 2, pp. 178-179. DOI: