Nanoscale Mass Transport Through the Body

General Problem 1

To formulate the governing laws of transport of nanoscale mass through the body.

  • Simplified Problem 1 (SP1): To formulate the governing laws of transport of (synthetic) nanoscale particles across a biological barrier of the body, or a system thereof.
  • Simplified Problem 2 (SP2): To design synthetic nanoscale particles to penetrate preferentially across a biological barrier of the body, or a system thereof.
  • Simplified Problem 3 (SP3): To determine and express the laws of transport across biological barriers for a given nanoparticle probe (contrast agent) in terms of quantities that can be observed and measured in vivo, using the (radiological) modality that is associated with the given nanoparticle probe (contrast agent).
  • Simplified Problem 4 (SP4): To identify the governing laws for specific transport of a nanoparticle across (a system of) biobarriers, as a function of the nanoparticle parameters. When (a subset of) these have an opposing effect, to identify the “borderline” conditions under which successful transport is possible, and therapeutic efficacy may be expected.