Copeland lab Publications


A recellularized human colon model identifies cancer driver genes
Chen, HJ, Wei, Z, Sun, J, Bhattacharya, A, Savage, DJ, Serda, R, Mackeyev, Y, Curley, SA, Bu, P, Wang, L, Chen, S, Cohen-Gould, L, Huang, E, Shen, X, Lipkin, SM, Copeland, NG, Jenkins, NA & Shuler, ML 2016, Nature Biotechnology, vol 34, no. 8, pp. 845-851. DOI:

Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma
Kodama, T, Newberg, JY, Kodama, M, Rangel, R, Yoshihara, K, Tien, JC, Parsons, PH, Wu, H, Finegold, MJ, Copeland, N & Jenkins, NA 2016, Proceedings of the National Academy of Sciences of the United States of America, vol 113, no. 24, pp. E3384-E3393. DOI:

Sleeping Beauty transposon mutagenesis identifies genes that cooperate with mutant Smad4 in gastric cancer development
Takeda, H, Rust, AG, Ward, JM, Yew, CCK, Jenkins, NA & Copeland, N 2016, Proceedings of the National Academy of Sciences of the United States of America, vol 113, no. 14, pp. E2057-E2065. DOI:

Structure-function integrity of the adult hippocampus depends on the transcription factor Bcl11b/Ctip2
Simon, R, Baumann, L, Fischer, J, Seigfried, FA, De Bruyckere, E, Liu, P, Jenkins, NA, Copeland, NG, Schwegler, H & Britsch, S 2016, Genes, Brain and Behavior, vol 15, no. 4, pp. 405-419. DOI:

Loss of the transcription factor Meis1 prevents sympathetic neurons target-field innervation and increases susceptibility to sudden cardiac death
Bouilloux, F, Thireau, J, Ventéo, S, Farah, C, Karam, S, Dauvilliers, Y, Valmier, J, Copeland, NG, Jenkins, NA, Richard, S & Marmigère, F 2016, eLife, vol 5, no. FEBRUARY2016, e11627. DOI:

Two-Step Forward Genetic Screen in Mice Identifies Ral GTPase-Activating Proteins as Suppressors of Hepatocellular Carcinoma
Kodama, T, Bard-Chapeau, EA, Newberg, JY, Kodama, M, Rangel, R, Yoshihara, K, Ward, JM, Jenkins, NA & Copeland, NG 2015, Gastroenterology. DOI:

Cardiomyocyte-specific overexpression of the ubiquitin ligase Wwp1 contributes to reduction in Connexin 43 and arrhythmogenesis
Basheer, WA, Harris, BS, Mentrup, HL, Abreha, M, Thames, EL, Lea, JB, Swing, DA, Copeland, NG, Jenkins, NA, Price, RL & Matesic, LE 2015, Journal of Molecular and Cellular Cardiology, vol 88, 8184, pp. 1-13. DOI:

Bcl11a (Ctip1) Controls Migration of Cortical Projection Neurons through Regulation of Sema3c
Wiegreffe, C, Simon, R, Peschkes, K, Kling, C, Strehle, M, Cheng, J, Srivatsa, S, Liu, P, Jenkins, NA, Copeland, NG, Tarabykin, V & Britsch, S 2015, Neuron, vol 87, no. 2, pp. 311-326. DOI:

The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development
Yu, Y, Wang, C, Clare, S, Wang, J, Lee, SC, Brandt, C, Burke, S, Lu, L, He, D, Jenkins, NA, Copeland, NG, Dougan, G & Liu, P 2015, The Journal of experimental medicine, vol 212, no. 6, pp. 865-74. DOI:

Transposon mutagenesis identifies genetic drivers of Braf V600E melanoma
Mann, MB, Black, MA, Jones, DJ, Ward, JM, Yew, CCK, Newberg, JY, Dupuy, AJ, Rust, AG, Bosenberg, MW, Mcmahon, M, Print, CG, Copeland, NG & Jenkins, NA 2015, Nature Genetics, vol 47, no. 5, pp. 486-495. DOI:

BCL11A is a Triple-negative breast cancer gene with critical functions in stem and progenitor cells
Khaled, WT, Lee, SC, Stingl, J, Chen, X, Ali, HR, Rueda, OM, Hadi, F, Wang, J, Yu, Y, Chin, SF, Stratton, M, Futreal, A, Jenkins, NA, Aparicio, S, Copeland, NG, Watson, CJ, Caldas, C & Liu, P 2015, Nature communications, vol 6, 6987, pp. 5987. DOI:

Identification of FoxR2 as an oncogene in medulloblastoma
Koso, H, Tsuhako, A, Lyons, E, Ward, JM, Rust, AG, Adams, DJ, Jenkins, NA, Copeland, NG & Watanabe, S 2014, Cancer Research, vol 74, no. 8, pp. 2351-2361. DOI:

Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects
Bard-Chapeau, EA, Szumska, D, Jacob, B, Chua, BQL, Chatterjee, GC, Zhang, Y, Ward, JM, Urun, F, Kinameri, E, Vincent, SD, Ahmed, S, Bhattacharya, S, Osato, M, Perkins, AS, Moore, AW, Jenkins, NA & Copeland, NG 2014, PLoS ONE, vol 9, no. 2, e89397. DOI:

Sleeping Beauty mutagenesis: Exploiting forward genetic screens for cancer gene discovery
Mann, MB, Jenkins, NA, Copeland, NG & Mann, KM 2014, Current Opinion in Genetics and Development, vol 24, no. 1, pp. 16-22. DOI:

LIM Domain Only-2 (LMO2) induces T-cell leukemia by two distinct pathways
Smith, S, Tripathi, R, Goodings, C, Cleveland, S, Mathias, E, Hardaway, JA, Elliott, N, Yi, Y, Chen, X, Downing, J, Mullighan, C, Swing, DA, Tessarollo, L, Li, Q, Love, P, Jenkins, NA, Copeland, NG, Thompson, MA, Du, Y & Davé, UP 2014, PLoS ONE, vol 9, no. 1. DOI:

Mutation of murine Sox4 untranslated regions results in partially penetrant perinatal lethality
Wiles, WG, Mou, Z, Du, Y, Long, AB, Scharer, CD, Bilir, B, Spyropoulos, DD, Jenkins, NA, Copeland, NG, Martin, WD & Moreno, CS 2014, In Vivo, vol 28, no. 5, pp. 709-718.

Transposon insertional mutagenesis models of cancer
Mann, KM, Jenkins, NA, Copeland, NG & Mann, MB 2014, Cold Spring Harbor Protocols, vol 2014, no. 3, pp. 235-247. DOI:

Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse model
Bard-Chapeau, EA, Nguyen, AT, Rust, AG, Sayadi, A, Lee, P, Chua, BQ, New, LS, De Jong, J, Ward, JM, Chin, CKY, Chew, V, Toh, HC, Abastado, JP, Benoukraf, T, Soong, R, Bard, FA, Dupuy, AJ, Johnson, RL, Radda, GK, Chan, ECY, Wessels, LFA, Adams, DJ, Jenkins, NA & Copeland, NG 2014, Nature Genetics, vol 46, no. 1, pp. 24-32. DOI:

Scrib is required for epithelial cell identity and prevents epithelial to mesenchymal transition in the mouse
Yamben, IF, Rachel, RA, Shatadal, S, Copeland, NG, Jenkins, NA, Warming, S & Griep, AE 2013, Developmental Biology, vol 384, no. 1, pp. 41-52. DOI:

Sleeping Beauty mutagenesis in a mouse medulloblastoma model defines networks that discriminate between human molecular subgroups
Genovesi, LA, Ng, CG, Davis, MJ, Remke, M, Taylor, MD, Adams, DJ, Rust, AG, Ward, JM, Ban, KH, Jenkins, NA, Copeland, NG & Wainwright, BJ 2013, Proceedings of the National Academy of Sciences of the United States of America, vol 110, no. 46. DOI: